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What is Immunodeficiency?

The following are congenital diseases that cause immunodeficiency : Canine Leucocyte Adhesion Deficiency / Canine Granulocytopathy SyndromeCanine granulocytopathy syndrome (now called canine leucocyte adehesion deficiency) has been reported to be an inherited autosomal recessive trait in Irish Setters and the condition has been reviewed recently in a report (Trowald-Wigh G. et al Journal of Small Animal Practice (2000) Vol41 p211-217). With this disorder neutrophils have impaired phagocytosis and have impaired ability to kill bacteria due to lack of adhesion proteins (integrins CD11b/CD18, b2-integrins). Deficiency of these proteins prevents leucocytes from leaving blood vessels - so poor numbers are found in tissues...

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