News — Canine Leucocyte Adhesion Deficiency

What is Immunodeficiency?

Dec 30, 2016 Audra Lynn

Tags abnormal platelets, Albinism, albinism coat, albinism iris, anorexia, B-cell, bacterial infection, Basenji, Beagles, bojne marrow transplant, Bordatella, bovine grwoth hormone, Bull Terriers, C3 Deficiency, Canine Granulocytopathy Syndrome, Canine Leucocyte Adhesion Deficiency, Chediak-Higashi Syndrome, Combines Immunodeficiency, Cyclic Haematopoiesis of Grey Collies, Death, dermatitis, Dilution of hair color, Disorders, footpad, Foxhounds, German Shepherd, Gingivitis, Growth Hormone Deficiency, haemorrhages, Haemorrhagesgastrointestinal infections, heose monophosphate, Hight white blood cell, Inappetance, infection of umbilicus, infections, interstitial pneumonia, Irish Setters, Lethal Acrodermatitis, lithium Carbonate, Lymph Node Enlargement, Metaphyseal Osteodystrophy, neutrophil, Neutrophlis, omphalophlebitis, paronechia, Parvovirus, Pelger-Huet Anomaly, photophobia, Poor growth rate, Poorly healing wounds, Post-natal infection, premature death, QZ, Radius, Respiratory disease, respiratory infection, Seizures, sever infections, Shar Pei, Skin disease, T-cell, Ulna, Zinc deficiency, `

The following are congenital diseases that cause immunodeficiency : Canine Leucocyte Adhesion Deficiency / Canine Granulocytopathy SyndromeCanine granulocytopathy syndrome (now called canine leucocyte adehesion deficiency) has been reported to be an inherited autosomal recessive trait in Irish Setters and the condition has been reviewed recently in a report (Trowald-Wigh G. et al Journal of Small Animal Practice (2000) Vol41 p211-217). With this disorder neutrophils have impaired phagocytosis and have impaired ability to kill bacteria due to lack of adhesion proteins (integrins CD11b/CD18, b2-integrins). Deficiency of these proteins prevents leucocytes from leaving blood vessels - so poor numbers are found in tissues...